NK2012 Heidelberg

12:00

Registration open

14:00-14:15

Welcome

Heidi Cerwenka

14:15-15:15

Session 1
NK Receptors, Education
Chair: Markus Uhrberg

Marco Colonna
Diversity and functions of innate lymphoid cells in the gastrointestinal mucosa

Petter Höglund
Phenotypic and functional correlates in NK cell education

15:15-15:45
3x10 min talks

Talks from abstracts

Leibelt/Steinle
Restricted tissue expression of NKC-encoded mouse Clr molecules suggests involvement in dedicated tissue-specific-immunosurveillance

Urlaub/Watzl
Crosstalk of activating NK cell receptors controls adhesion and cytotoxicity

Spanholtz/Dolstra
Comparison of human ex vivo and in vivo NK cell development

15:45-16:15

Coffee break

16:15-17:15

Keynote session

Günter J. Hämmerling
Control of tumor immunity by the microenvironment

17:15-18:15

Poster preview I
Chair: Carsten Watzl

18:15-18:30

General Assembly of the NK cell group in the German Society for Immunology

Ca. 18:15

Poster session I

Get together im KOZ
Fingerfood 18-21h

9:00-10:00

Session 2
Tumor models
Chair: Annette Paschen

Mark Smyth
NK cell recognition of cancer and metastases

Veronika Sexl
STATs in the spotlight

10:00-10:30
3x 10 min talks

Talks from abstracts

Glatzer/Romagnani
The activating receptor NKp44 elicits inflammatory signatures in RORgt+ innate lymphoid cells

Fiegler/Cerwenka
Expression and regulation of the activating NKp30 ligand B7-H6 on tumor cells

Borchmann/Pogge
Targeting the NKG2D Receptor on Natural Killer Cells: In Vivo anti-tumor activity of the bispecific Immunoligand ULBP2 scFvCEA

10:30-11:00

Coffee break

11:00-12.00

Session 3
Human tumors
Chair: Evelyn Ullrich

Laurence Zitvogel
NK cell immunosurveillance in human GIST malignancies

Eric Vivier
NK cell recognition strategies

12:00-12:30
3 x 10 min talks

Talks from abstracts

Hilpert/Salih
Bimodal induction of NK cell reactivity against acute myeloid (AML) and chronic lymphoid leukemia (CLL) by Fc-engineered GITR-Fc fusion proteins

Oevermann/Handgretinger
Reduced risk of relapse in pedriatric ALL after haploidentical transplantation of T-cell depleted grafts from KIR haplotype B donors

Koehl/Schwabe
NK cells for adoptive therapy of high risk patients with neuroblastoma or head and neck squamous cell carcinoma

12:30-14:00

Lunch DKFZ, KOZ

“Meet the Speakers” for students

14:00-15:00

Session 4
NK cells in clinics
Chair: Christine Falk

Andrea Velardi
Harnessing natural and adaptive immunity after haploidentical hematopoietic
cell transplantation

Daniela Pende
NK cells in patients with cytolytic defects and in transplanted leukemic patients

15:00-15:30

Coffee break

15:30-16:45

Panel discussion

NK cell based immunotherapy of cancer

16:45-18:00

Poster preview II
Chair: Frank Momburg

18:00-19:30

Poster session II

20:00

Dinner party

9:00-10:00

Session 5
NK cells in Pregnancy and Infection
Chair: Alexander Steinle

Francesco Colucci
NK cells meet invasive cells: consequences on malignancy and reproduction

Ofer Mandelboim
Recognition of viruses by NK cells

10:00-10:30
3 x 10 min talks

Talks from abstracts

Chatterjee/Jacobs
Functional interactions between human mesenchymal stem cells and NK cells

Ganal/Diefenbach
Priming of natural killer cells by non-mucosal mononuclear phagocytes requires instructive signals from the commensal microbiota

Knoll/Bogdan
Neutrophils Modulate the Activation of NK Cells in Visceral Leishmaniasis

10:30-11:00

Coffee break

11:00-11:30

Session 6
NK cells and virus
Chair: Andreas Diefenbach

Lewis Lanier
NK cell memory

11:30-12:10
3 x10 min talks

Talks from abstracts

Babic Cac/Jonjic:
Highly abundant MCMV transcript with coding and non-coding functions is necessary for recognition of m04/MHC I complex by activating Ly49 receptors

Jarahian/Momburg
Modulation of NKp30- and NKp46-mediated natural killer cell responses by poxviral hemagglutinin

Jansen/Vervelde
Diminished lung NK-cell responses upon infection with highly pathogenic avian influenza virus may contribute to pathogenicity

Varchetta/Mondelli
Modulation of soluble and NK cell-expressed sialic-acid-binding immunoglobulin-like lectin-7 (Siglec-7) in patients with chronic hepatitis C virus (HCV) infection

12:10-13:00

“Snack”  DKFZ

Departure